diff --git a/src/serena/cli.py b/src/serena/cli.py
index 73aeb6c9..33595e70 100644
--- a/src/serena/cli.py
+++ b/src/serena/cli.py
@@ -637,7 +637,7 @@ class ProjectCommands(AutoRegisteringGroup):
         lvl = logging.getLevelNamesMapping()[log_level.upper()]
         logging.configure(level=lvl)
         serena_config = SerenaConfig.from_config_file()
-        proj = registered_project.get_project_instance()
+        proj = registered_project.get_project_instance(serena_config=serena_config)
         click.echo(f"Indexing symbols in {proj} …")
         ls_mgr = proj.create_language_server_manager(
             log_level=lvl, ls_timeout=timeout, ls_specific_settings=serena_config.ls_specific_settings
@@ -690,7 +690,8 @@ class ProjectCommands(AutoRegisteringGroup):
         :param path: The path to check.
         :param project: The path to the project directory, defaults to the current working directory.
         """
-        proj = Project.load(os.path.abspath(project))
+        serena_config = SerenaConfig.from_config_file()
+        proj = Project.load(os.path.abspath(project), serena_config=serena_config)
         if os.path.isabs(path):
             path = os.path.relpath(path, start=proj.project_root)
         is_ignored = proj.is_ignored_path(path)
@@ -712,7 +713,8 @@ class ProjectCommands(AutoRegisteringGroup):
         :param project: path to the project directory, defaults to the current working directory.
         :param verbose: if set, prints detailed information about the indexed symbols.
         """
-        proj = Project.load(os.path.abspath(project))
+        serena_config = SerenaConfig.from_config_file()
+        proj = Project.load(os.path.abspath(project), serena_config=serena_config)
         if os.path.isabs(file):
             file = os.path.relpath(file, start=proj.project_root)
         if proj.is_ignored_path(file, ignore_non_source_files=True):
@@ -749,7 +751,8 @@ class ProjectCommands(AutoRegisteringGroup):
         # NOTE: completely written by Claude Code, only functionality was reviewed, not implementation
         logging.configure(level=logging.INFO)
         project_path = os.path.abspath(project)
-        proj = Project.load(project_path)
+        serena_config = SerenaConfig.from_config_file()
+        proj = Project.load(project_path, serena_config=serena_config)
 
         # Create log file with timestamp
         timestamp = datetime_tag()
diff --git a/src/serena/config/serena_config.py b/src/serena/config/serena_config.py
index 5f6b3fe6..6599a591 100644
--- a/src/serena/config/serena_config.py
+++ b/src/serena/config/serena_config.py
@@ -397,12 +397,18 @@ class ProjectConfig(ToolInclusionDefinition, ModeSelectionDefinition, ToStringMi
 
 
 class RegisteredProject(ToStringMixin):
-    def __init__(self, project_root: str, project_config: "ProjectConfig", project_instance: Optional["Project"] = None) -> None:
+    def __init__(
+        self,
+        project_root: str,
+        project_config: "ProjectConfig",
+        project_instance: Optional["Project"] = None,
+    ) -> None:
         """
         Represents a registered project in the Serena configuration.
 
         :param project_root: the root directory of the project
         :param project_config: the configuration of the project
+        :param project_instance: an existing project instance (if already loaded)
         """
         self.project_root = Path(project_root).resolve()
         self.project_config = project_config
@@ -440,7 +446,7 @@ class RegisteredProject(ToStringMixin):
         """
         return self.project_root.samefile(Path(path).resolve())
 
-    def get_project_instance(self) -> "Project":
+    def get_project_instance(self, serena_config: "SerenaConfig | None") -> "Project":
         """
         Returns the project instance for this registered project, loading it if necessary.
         """
@@ -448,7 +454,11 @@ class RegisteredProject(ToStringMixin):
             from ..project import Project
 
             with LogTime(f"Loading project instance for {self}", logger=log):
-                self._project_instance = Project(project_root=str(self.project_root), project_config=self.project_config)
+                self._project_instance = Project(
+                    project_root=str(self.project_root),
+                    project_config=self.project_config,
+                    serena_config=serena_config,
+                )
         return self._project_instance
 
 
@@ -493,6 +503,10 @@ class SerenaConfig(ToolInclusionDefinition, ModeSelectionDefinition, ToStringMix
     ls_specific_settings: dict = field(default_factory=dict)
     """Advanced configuration option allowing to configure language server implementation specific options, see SolidLSPSettings for more info."""
 
+    ignored_paths: list[str] = field(default_factory=list)
+    """List of paths to ignore across all projects. Same syntax as gitignore, so you can use * and **.
+    These patterns are merged additively with each project's own ignored_paths."""
+
     # settings with overridden defaults
     default_modes: Sequence[str] | None = ("interactive", "editing")
 
@@ -724,7 +738,7 @@ class SerenaConfig(ToolInclusionDefinition, ModeSelectionDefinition, ToStringMix
         if registered_project is None:
             return None
         else:
-            return registered_project.get_project_instance()
+            return registered_project.get_project_instance(serena_config=self)
 
     def add_registered_project(self, registered_project: RegisteredProject) -> None:
         """
@@ -758,7 +772,12 @@ class SerenaConfig(ToolInclusionDefinition, ModeSelectionDefinition, ToStringMix
 
         project_config = ProjectConfig.load(project_root, autogenerate=True)
 
-        new_project = Project(project_root=str(project_root), project_config=project_config, is_newly_created=True)
+        new_project = Project(
+            project_root=str(project_root),
+            project_config=project_config,
+            is_newly_created=True,
+            serena_config=self,
+        )
         self.add_registered_project(RegisteredProject.from_project_instance(new_project))
 
         return new_project
diff --git a/src/serena/project.py b/src/serena/project.py
index ea3674ad..c176dddb 100644
--- a/src/serena/project.py
+++ b/src/serena/project.py
@@ -3,7 +3,7 @@ import logging
 import os
 import threading
 from pathlib import Path
-from typing import Any
+from typing import TYPE_CHECKING, Any
 
 import pathspec
 from sensai.util.logging import LogTime
@@ -18,6 +18,9 @@ from solidlsp import SolidLanguageServer
 from solidlsp.ls_config import Language
 from solidlsp.ls_utils import FileUtils
 
+if TYPE_CHECKING:
+    from serena.config.serena_config import SerenaConfig
+
 log = logging.getLogger(__name__)
 
 
@@ -56,7 +59,13 @@ class MemoriesManager:
 
 
 class Project(ToStringMixin):
-    def __init__(self, project_root: str, project_config: ProjectConfig, is_newly_created: bool = False):
+    def __init__(
+        self,
+        project_root: str,
+        project_config: ProjectConfig,
+        is_newly_created: bool = False,
+        serena_config: "SerenaConfig | None" = None,
+    ):
         self.project_root = project_root
         self.project_config = project_config
         self.memories_manager = MemoriesManager(project_root)
@@ -72,6 +81,7 @@ class Project(ToStringMixin):
                 f.write(f"/{SolidLanguageServer.CACHE_FOLDER_NAME}\n")
 
         # prepare ignore spec asynchronously, ensuring immediate project activation.
+        self._serena_config = serena_config
         self.__ignored_patterns: list[str]
         self.__ignore_spec: pathspec.PathSpec
         self._ignore_spec_available = threading.Event()
@@ -80,11 +90,16 @@ class Project(ToStringMixin):
     def _gather_ignorespec(self) -> None:
         with LogTime(f"Gathering ignore spec for project {self.project_config.project_name}", logger=log):
 
-            # gather ignored paths from the project configuration and gitignore files
-            ignored_patterns = list(self.project_config.ignored_paths)
-            if len(ignored_patterns) > 0:
-                log.info(f"Using {len(ignored_patterns)} ignored paths from the explicit project configuration.")
-                log.debug(f"Ignored paths: {ignored_patterns}")
+            # gather ignored paths from the global configuration, project configuration, and gitignore files
+            global_ignored_paths = self._serena_config.ignored_paths if self._serena_config else []
+            ignored_patterns = list(global_ignored_paths) + list(self.project_config.ignored_paths)
+            if len(global_ignored_paths) > 0:
+                log.info(f"Using {len(global_ignored_paths)} ignored paths from the global configuration.")
+                log.debug(f"Global ignored paths: {list(global_ignored_paths)}")
+            if len(self.project_config.ignored_paths) > 0:
+                log.info(f"Using {len(self.project_config.ignored_paths)} ignored paths from the project configuration.")
+                log.debug(f"Project ignored paths: {self.project_config.ignored_paths}")
+            log.debug(f"Combined ignored patterns: {ignored_patterns}")
             if self.project_config.ignore_all_files_in_gitignore:
                 gitignore_parser = GitignoreParser(self.project_root)
                 for spec in gitignore_parser.get_ignore_specs():
@@ -115,12 +130,17 @@ class Project(ToStringMixin):
         return self.project_config.project_name
 
     @classmethod
-    def load(cls, project_root: str | Path, autogenerate: bool = True) -> "Project":
+    def load(
+        cls,
+        project_root: str | Path,
+        serena_config: "SerenaConfig | None",
+        autogenerate: bool = True,
+    ) -> "Project":
         project_root = Path(project_root).resolve()
         if not project_root.exists():
             raise FileNotFoundError(f"Project root not found: {project_root}")
         project_config = ProjectConfig.load(project_root, autogenerate=autogenerate)
-        return Project(project_root=str(project_root), project_config=project_config)
+        return Project(project_root=str(project_root), project_config=project_config, serena_config=serena_config)
 
     def save_config(self) -> None:
         """
diff --git a/src/serena/resources/project.template.yml b/src/serena/resources/project.template.yml
index 1ce23a99..8276989d 100644
--- a/src/serena/resources/project.template.yml
+++ b/src/serena/resources/project.template.yml
@@ -34,8 +34,9 @@ encoding: "utf-8"
 # whether to use project's .gitignore files to ignore files
 ignore_all_files_in_gitignore: true
 
-# list of additional paths to ignore in all projects
-# same syntax as gitignore, so you can use * and **
+# list of additional paths to ignore in this project.
+# Same syntax as gitignore, so you can use * and **.
+# Note: global ignored_paths from serena_config.yml are also applied additively.
 ignored_paths: []
 
 # whether the project is in read-only mode
diff --git a/src/serena/resources/serena_config.template.yml b/src/serena/resources/serena_config.template.yml
index 7a660e64..ac11088e 100644
--- a/src/serena/resources/serena_config.template.yml
+++ b/src/serena/resources/serena_config.template.yml
@@ -63,6 +63,11 @@ trace_lsp_communication: False
 # No documentation on options means no options are available.
 ls_specific_settings: {}
 
+# list of paths to ignore across all projects.
+# Same syntax as gitignore, so you can use * and **.
+# These patterns are merged additively with each project's own ignored_paths.
+ignored_paths: []
+
 # timeout, in seconds, after which tool executions are terminated
 tool_timeout: 240
 
diff --git a/test/conftest.py b/test/conftest.py
index 822006f2..85d38a05 100644
--- a/test/conftest.py
+++ b/test/conftest.py
@@ -116,7 +116,7 @@ def start_default_ls_context(language: Language) -> Iterator[SolidLanguageServer
 
 def _create_default_project(language: Language) -> Project:
     repo_path = str(get_repo_path(language))
-    return Project.load(repo_path)
+    return Project.load(repo_path, serena_config=None)
 
 
 @pytest.fixture(scope="session")
diff --git a/test/serena/config/test_global_ignored_paths.py b/test/serena/config/test_global_ignored_paths.py
new file mode 100644
index 00000000..23481373
--- /dev/null
+++ b/test/serena/config/test_global_ignored_paths.py
@@ -0,0 +1,261 @@
+import os
+import shutil
+import tempfile
+from pathlib import Path
+
+from serena.config.serena_config import ProjectConfig, RegisteredProject, SerenaConfig
+from serena.project import Project
+from solidlsp.ls_config import Language
+
+
+def _create_test_project(
+    project_root: Path,
+    project_ignored_paths: list[str] | None = None,
+    global_ignored_paths: list[str] | None = None,
+) -> Project:
+    """Helper to create a Project with the given ignored paths configuration."""
+    config = ProjectConfig(
+        project_name="test_project",
+        languages=[Language.PYTHON],
+        ignored_paths=project_ignored_paths or [],
+        ignore_all_files_in_gitignore=False,
+    )
+    serena_config: SerenaConfig | None = None
+    if global_ignored_paths:
+        serena_config = SerenaConfig(gui_log_window=False, web_dashboard=False, ignored_paths=global_ignored_paths)
+    return Project(
+        project_root=str(project_root),
+        project_config=config,
+        serena_config=serena_config,
+    )
+
+
+class TestGlobalIgnoredPaths:
+    """Tests for system-global ignored_paths feature."""
+
+    def setup_method(self) -> None:
+        self.test_dir = tempfile.mkdtemp()
+        self.project_path = Path(self.test_dir)
+        # Create some test files and directories
+        (self.project_path / "main.py").write_text("print('hello')")
+        os.makedirs(self.project_path / "node_modules" / "pkg", exist_ok=True)
+        (self.project_path / "node_modules" / "pkg" / "index.js").write_text("module.exports = {}")
+        os.makedirs(self.project_path / "build", exist_ok=True)
+        (self.project_path / "build" / "output.js").write_text("compiled")
+        os.makedirs(self.project_path / "src", exist_ok=True)
+        (self.project_path / "src" / "app.py").write_text("def app(): pass")
+        (self.project_path / "debug.log").write_text("log data")
+
+    def teardown_method(self) -> None:
+        shutil.rmtree(self.test_dir)
+
+    def test_global_ignored_paths_are_applied(self) -> None:
+        """Global ignored_paths from SerenaConfig are respected by Project.is_ignored_path()."""
+        project = _create_test_project(
+            self.project_path,
+            global_ignored_paths=["node_modules"],
+        )
+        assert project.is_ignored_path(str(self.project_path / "node_modules" / "pkg" / "index.js"))
+        assert not project.is_ignored_path(str(self.project_path / "src" / "app.py"))
+
+    def test_additive_merge_of_global_and_project_patterns(self) -> None:
+        """Global + project patterns are merged additively (both applied)."""
+        project = _create_test_project(
+            self.project_path,
+            project_ignored_paths=["build"],
+            global_ignored_paths=["node_modules"],
+        )
+        # Global pattern should be applied
+        assert project.is_ignored_path(str(self.project_path / "node_modules" / "pkg" / "index.js"))
+        # Project pattern should also be applied
+        assert project.is_ignored_path(str(self.project_path / "build" / "output.js"))
+        # Non-ignored files should not be affected
+        assert not project.is_ignored_path(str(self.project_path / "src" / "app.py"))
+
+    def test_empty_global_ignored_paths_has_no_effect(self) -> None:
+        """Empty global ignored_paths (default) has no effect on existing behavior."""
+        project = _create_test_project(
+            self.project_path,
+            project_ignored_paths=["build"],
+            global_ignored_paths=[],
+        )
+        # Project pattern still works
+        assert project.is_ignored_path(str(self.project_path / "build" / "output.js"))
+        # Non-ignored files still accessible
+        assert not project.is_ignored_path(str(self.project_path / "node_modules" / "pkg" / "index.js"))
+
+    def test_default_global_ignored_paths_backward_compatible(self) -> None:
+        """Project created without global_ignored_paths parameter works as before."""
+        config = ProjectConfig(
+            project_name="test_project",
+            languages=[Language.PYTHON],
+            ignored_paths=["build"],
+            ignore_all_files_in_gitignore=False,
+        )
+        project = Project(
+            project_root=str(self.project_path),
+            project_config=config,
+        )
+        assert project.is_ignored_path(str(self.project_path / "build" / "output.js"))
+        assert not project.is_ignored_path(str(self.project_path / "node_modules" / "pkg" / "index.js"))
+
+    def test_duplicate_patterns_across_global_and_project(self) -> None:
+        """Duplicate patterns across global and project do not cause errors."""
+        project = _create_test_project(
+            self.project_path,
+            project_ignored_paths=["node_modules", "build"],
+            global_ignored_paths=["node_modules", "build"],
+        )
+        assert project.is_ignored_path(str(self.project_path / "node_modules" / "pkg" / "index.js"))
+        assert project.is_ignored_path(str(self.project_path / "build" / "output.js"))
+        assert not project.is_ignored_path(str(self.project_path / "src" / "app.py"))
+
+    def test_glob_patterns_in_global_ignored_paths(self) -> None:
+        """Global ignored_paths support gitignore-style glob patterns."""
+        project = _create_test_project(
+            self.project_path,
+            global_ignored_paths=["*.log"],
+        )
+        assert project.is_ignored_path(str(self.project_path / "debug.log"))
+        assert not project.is_ignored_path(str(self.project_path / "main.py"))
+
+
+class TestRegisteredProjectGlobalIgnoredPaths:
+    """RegisteredProject.get_project_instance() correctly passes global patterns to Project."""
+
+    def setup_method(self) -> None:
+        self.test_dir = tempfile.mkdtemp()
+        self.project_path = Path(self.test_dir).resolve()
+        (self.project_path / "main.py").write_text("print('hello')")
+        os.makedirs(self.project_path / "node_modules", exist_ok=True)
+        (self.project_path / "node_modules" / "pkg.js").write_text("module")
+
+    def teardown_method(self) -> None:
+        shutil.rmtree(self.test_dir)
+
+    def test_get_project_instance_passes_global_ignored_paths(self) -> None:
+        """RegisteredProject.get_project_instance() passes global_ignored_paths to Project."""
+        config = ProjectConfig(
+            project_name="test_project",
+            languages=[Language.PYTHON],
+            ignored_paths=[],
+            ignore_all_files_in_gitignore=False,
+        )
+        serena_config = SerenaConfig(gui_log_window=False, web_dashboard=False, ignored_paths=["node_modules"])
+        registered = RegisteredProject(
+            project_root=str(self.project_path),
+            project_config=config,
+        )
+        project = registered.get_project_instance(serena_config=serena_config)
+        assert project.is_ignored_path(str(self.project_path / "node_modules" / "pkg.js"))
+
+    def test_get_project_instance_without_global_ignored_paths(self) -> None:
+        """RegisteredProject without global_ignored_paths defaults to empty."""
+        config = ProjectConfig(
+            project_name="test_project",
+            languages=[Language.PYTHON],
+            ignored_paths=[],
+            ignore_all_files_in_gitignore=False,
+        )
+        registered = RegisteredProject(
+            project_root=str(self.project_path),
+            project_config=config,
+        )
+        project = registered.get_project_instance(serena_config=None)
+        assert not project.is_ignored_path(str(self.project_path / "node_modules" / "pkg.js"))
+
+    def test_from_project_root_passes_global_ignored_paths(self) -> None:
+        """RegisteredProject.from_project_root() threads global_ignored_paths to Project."""
+        # Create a minimal project.yml so from_project_root can load config
+        serena_dir = self.project_path / ".serena"
+        serena_dir.mkdir(exist_ok=True)
+        (serena_dir / "project.yml").write_text(
+            'project_name: "test_project"\nlanguages: ["python"]\nignored_paths: []\nignore_all_files_in_gitignore: false\n'
+        )
+        serena_config = SerenaConfig(gui_log_window=False, web_dashboard=False, ignored_paths=["node_modules"])
+        registered = RegisteredProject.from_project_root(
+            str(self.project_path),
+        )
+        project = registered.get_project_instance(serena_config=serena_config)
+        assert project.is_ignored_path(str(self.project_path / "node_modules" / "pkg.js"))
+
+    def test_from_project_instance_passes_global_ignored_paths(self) -> None:
+        """RegisteredProject.from_project_instance() threads global_ignored_paths to Project."""
+        config = ProjectConfig(
+            project_name="test_project",
+            languages=[Language.PYTHON],
+            ignored_paths=[],
+            ignore_all_files_in_gitignore=False,
+        )
+        serena_config = SerenaConfig(gui_log_window=False, web_dashboard=False, ignored_paths=["node_modules"])
+        project = Project(
+            project_root=str(self.project_path),
+            project_config=config,
+            serena_config=serena_config,
+        )
+        registered = RegisteredProject.from_project_instance(project)
+        # The registered project already has a project_instance, so get_project_instance() returns it directly
+        retrieved = registered.get_project_instance(serena_config=serena_config)
+        assert retrieved.is_ignored_path(str(self.project_path / "node_modules" / "pkg.js"))
+
+
+class TestGlobalIgnoredPathsWithGitignore:
+    """Global ignored_paths combined with ignore_all_files_in_gitignore produces correct three-way merge."""
+
+    def setup_method(self) -> None:
+        self.test_dir = tempfile.mkdtemp()
+        self.project_path = Path(self.test_dir).resolve()
+        # Create test files
+        (self.project_path / "main.py").write_text("print('hello')")
+        os.makedirs(self.project_path / "node_modules", exist_ok=True)
+        (self.project_path / "node_modules" / "pkg.js").write_text("module")
+        os.makedirs(self.project_path / "dist", exist_ok=True)
+        (self.project_path / "dist" / "bundle.js").write_text("bundled")
+        os.makedirs(self.project_path / "build", exist_ok=True)
+        (self.project_path / "build" / "output.js").write_text("compiled")
+        # Create .gitignore that ignores dist/
+        (self.project_path / ".gitignore").write_text("dist/\n")
+
+    def teardown_method(self) -> None:
+        shutil.rmtree(self.test_dir)
+
+    def test_three_way_merge_global_project_and_gitignore(self) -> None:
+        """Global patterns, project patterns, and .gitignore patterns are all applied together."""
+        config = ProjectConfig(
+            project_name="test_project",
+            languages=[Language.PYTHON],
+            ignored_paths=["build"],
+            ignore_all_files_in_gitignore=True,
+        )
+        serena_config = SerenaConfig(gui_log_window=False, web_dashboard=False, ignored_paths=["node_modules"])
+        project = Project(
+            project_root=str(self.project_path),
+            project_config=config,
+            serena_config=serena_config,
+        )
+        # Global pattern: node_modules
+        assert project.is_ignored_path(str(self.project_path / "node_modules" / "pkg.js"))
+        # Project pattern: build
+        assert project.is_ignored_path(str(self.project_path / "build" / "output.js"))
+        # Gitignore pattern: dist/
+        assert project.is_ignored_path(str(self.project_path / "dist" / "bundle.js"))
+        # Non-ignored file
+        assert not project.is_ignored_path(str(self.project_path / "main.py"))
+
+
+class TestSerenaConfigIgnoredPaths:
+    """Config loading with ignored_paths in serena_config.yml works correctly."""
+
+    def test_serena_config_default_ignored_paths(self) -> None:
+        """SerenaConfig defaults to empty ignored_paths."""
+        config = SerenaConfig(gui_log_window=False, web_dashboard=False)
+        assert config.ignored_paths == []
+
+    def test_serena_config_with_ignored_paths(self) -> None:
+        """SerenaConfig can be created with explicit ignored_paths."""
+        config = SerenaConfig(
+            gui_log_window=False,
+            web_dashboard=False,
+            ignored_paths=["node_modules", "*.log", "build"],
+        )
+        assert config.ignored_paths == ["node_modules", "*.log", "build"]